[Delayed neurotoxic action of a new fungicide aphos]. / Zamedlennoe neirotoksicheskoe deistvie novogo fungitsida afosa.

ABSTRACT

It has been established that administration of aphos to chickens within a wide dose range (3000-25 mg/kg) produces a retarded neurotoxic action that is manifested by the development of ataxia, pareses and paralyses; delay in the rate of the distribution of excitation via the peripheral axons, disorders of myoneural lability; degeneration of myelin fibers, focal granular degradation of myelin. The retarded neurotoxic action is not caused by impurities contained by the technical-grade preparation in view of the fact that such an action is also common to the chemically pure aphos.