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A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases.
Gorelik, Maryna; Manczyk, Noah; Pavlenco, Alevtina; Kurinov, Igor; Sidhu, Sachdev S; Sicheri, Frank.
Afiliação
  • Gorelik M; Banting and Best Department of Medical Research, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Manczyk N; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Pavlenco A; Banting and Best Department of Medical Research, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada.
  • Kurinov I; Department of Chemistry and Chemical Biology, Cornell University, Argonne, IL 60439, USA.
  • Sidhu SS; Banting and Best Department of Medical Research, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: sachdev.sidhu@utoronto.ca.
  • Sicheri F; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: sicheri@lunenfeld.ca.
Structure ; 26(9): 1226-1236.e3, 2018 09 04.
Article em En | MEDLINE | ID: mdl-30033217
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ubiquitinas / Proteínas Ligases SKP Culina F-Box Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ubiquitinas / Proteínas Ligases SKP Culina F-Box Idioma: En Ano de publicação: 2018 Tipo de documento: Article