Deferoxamine loaded titania nanotubes substrates regulate osteogenic and angiogenic differentiation of MSCs via activation of HIF-1&#945; signaling.

Ran, Qichun; Yu, Yonglin; Chen, Weizhen; Shen, Xinkun; Mu, Caiyun; Yuan, Zhang; Tao, Bailong; Hu, Yan; Yang, Weihu; Cai, Kaiyong

Deferoxamine loaded titania nanotubes substrates regulate osteogenic and angiogenic differentiation of MSCs via activation of HIF-1α signaling.

Ran, Qichun; Yu, Yonglin; Chen, Weizhen; Shen, Xinkun; Mu, Caiyun; Yuan, Zhang; Tao, Bailong; Hu, Yan; Yang, Weihu; Cai, Kaiyong.

Afiliação

Ran Q; Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing 400044, China.
Yu Y; Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing 400044, China.
Chen W; Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing 400044, China.
Shen X; Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing 400044, China.
Mu C; Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing 400044, China.
Yuan Z; Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing 400044, China.
Tao B; Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing 400044, China.
Hu Y; Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing 400044, China.
Yang W; Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing 400044, China. Electronic address: yangweihu@cqu.edu.cn.
Cai K; Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing 400044, China; Chongqing Collaborative Innovation Center for Minimally-invasive and Noninvasive Medicine, Chongqing 400016, China. Electronic address: kaiyong_cai

Mater Sci Eng C Mater Biol Appl ; 91: 44-54, 2018 Oct 01.

Article em En | MEDLINE | ID: mdl-30033275

Assuntos

Desferroxamina/farmacologia; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Células-Tronco Mesenquimais/citologia; Nanotubos/química; Neovascularização Fisiológica/efeitos dos fármacos; Osteogênese/efeitos dos fármacos; Transdução de Sinais; Titânio/química; Adsorção; Animais; Diferenciação Celular/genética; Proliferação de Células/genética; Forma Celular/genética; Regulação da Expressão Gênica/efeitos dos fármacos; Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos; Células Endoteliais da Veia Umbilical Humana/metabolismo; Humanos; Células-Tronco Mesenquimais/efeitos dos fármacos; Células-Tronco Mesenquimais/metabolismo; Microscopia de Força Atômica; Neovascularização Fisiológica/genética; Osteogênese/genética; Espectroscopia Fotoeletrônica; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Ratos Sprague-Dawley; Soroalbumina Bovina/química; Água/química

Palavras-chave

Differentiation; Drug release; Layer-by-layer assembly; MSCs; Titania nanotube

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteogênese / Titânio / Transdução de Sinais / Neovascularização Fisiológica / Desferroxamina / Nanotubos / Subunidade alfa do Fator 1 Induzível por Hipóxia / Células-Tronco Mesenquimais Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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