An outbreak of severe invasive meningococcal disease due to a capsular switched Neisseria meningitidis hypervirulent strain B:cc11.
Clin Microbiol Infect
; 25(1): 111.e1-111.e4, 2019 Jan.
Article
em En
| MEDLINE
| ID: mdl-30036673
ABSTRACT
OBJECTIVES:
The aim was to investigate an outbreak of invasive meningococcal disease (IMD) in Southern Sardinia.METHODS:
Epidemiological and microbiological investigations were performed. The latter included antimicrobial susceptibility testing and whole-genome sequencing (WGS).RESULTS:
Seven individuals with severe IMD were found to be infected with serogroup B (MenB) Neisseria meningitidis in the first quarter of 2018. Five of the seven cases (five males; mean age 19 years; range 18-21 years; CFR 40%) were due to a unique strain BP1.5-1,10-8F3-6ST-11(cc11), probably switched from the hypervirulent C-cc11, as confirmed by WGS. All five patients had attended the same nightclub in the 2 weeks prior to symptom onset. Public health measures, including chemoprophylaxis of contacts and active immunization against MenB, were implemented.CONCLUSIONS:
We observed five IMD cases due to the same switched MenB strain. The hypervirulent BP1.5-1,10-8F3-6ST-11(cc11) strain, probably switched from C-cc11, is of concern due to the observed high virulence and case fatality rates. All the patients shared the same place of probable exposure. The molecular characterization of the invasive strain allowed the outbreak to be confirmed, which was then controlled through timely public health action.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Surtos de Doenças
/
Cápsulas Bacterianas
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Infecções Meningocócicas
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Neisseria meningitidis
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article