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Exploration of Pyrrolobenzodiazepine (PBD)-Dimers Containing Disulfide-Based Prodrugs as Payloads for Antibody-Drug Conjugates.
Pei, Zhonghua; Chen, Chunjiao; Chen, Jinhua; Cruz-Chuh, Josefa Dela; Delarosa, Reginald; Deng, Yuzhong; Fourie-O'Donohue, Aimee; Figueroa, Isabel; Guo, Jun; Jin, Weiwei; Khojasteh, S Cyrus; Kozak, Katherine R; Latifi, Brandon; Lee, James; Li, Guangmin; Lin, Eva; Liu, Liling; Lu, Jiawei; Martin, Scott; Ng, Carl; Nguyen, Trung; Ohri, Rachana; Lewis Phillips, Gail; Pillow, Thomas H; Rowntree, Rebecca K; Stagg, Nicola J; Stokoe, David; Ulufatu, Sheila; Verma, Vishal A; Wai, John; Wang, Jing; Xu, Keyang; Xu, Zijin; Yao, Hui; Yu, Shang-Fan; Zhang, Donglu; Dragovich, Peter S.
Afiliação
  • Pei Z; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Chen C; WuXi Biologics, 288 Fute Zhong Road , Waigaoqiao Free Trade Zone, Shanghai 200131 , China.
  • Chen J; Wuxi Apptec , 288 Fute Zhong Road , Waigaoqiao Free Trade Zone, Shanghai 200131 , China.
  • Cruz-Chuh JD; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Delarosa R; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Deng Y; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Fourie-O'Donohue A; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Figueroa I; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Guo J; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Jin W; WuXi Biologics, 288 Fute Zhong Road , Waigaoqiao Free Trade Zone, Shanghai 200131 , China.
  • Khojasteh SC; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Kozak KR; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Latifi B; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Lee J; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Li G; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Lin E; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Liu L; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Lu J; WuXi Biologics, 288 Fute Zhong Road , Waigaoqiao Free Trade Zone, Shanghai 200131 , China.
  • Martin S; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Ng C; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Nguyen T; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Ohri R; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Lewis Phillips G; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Pillow TH; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Rowntree RK; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Stagg NJ; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Stokoe D; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Ulufatu S; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Verma VA; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Wai J; Wuxi Apptec , 288 Fute Zhong Road , Waigaoqiao Free Trade Zone, Shanghai 200131 , China.
  • Wang J; Wuxi Apptec , 288 Fute Zhong Road , Waigaoqiao Free Trade Zone, Shanghai 200131 , China.
  • Xu K; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Xu Z; Wuxi Apptec , 288 Fute Zhong Road , Waigaoqiao Free Trade Zone, Shanghai 200131 , China.
  • Yao H; Wuxi Apptec , 288 Fute Zhong Road , Waigaoqiao Free Trade Zone, Shanghai 200131 , China.
  • Yu SF; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Zhang D; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Dragovich PS; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
Mol Pharm ; 15(9): 3979-3996, 2018 09 04.
Article em En | MEDLINE | ID: mdl-30040421
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirróis / Benzodiazepinas / Pró-Fármacos / Imunoconjugados / Dissulfetos Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirróis / Benzodiazepinas / Pró-Fármacos / Imunoconjugados / Dissulfetos Idioma: En Ano de publicação: 2018 Tipo de documento: Article