Human papillomavirus (HPV) shedding in breast milk from African women living with HIV.
J Clin Virol
; 106: 41-43, 2018 09.
Article
em En
| MEDLINE
| ID: mdl-30041089
ABSTRACT
BACKGROUND:
Little is known about human papillomavirus (HPV) shedding in human breast milk.OBJECTIVE:
To investigate HPV shedding in mature breast milk specimens collected from breastfeeding African women living with HIV-1 and not receiving antiretroviral treatment.DESIGN:
62 African women enrolled in the ANRS 12174 trial participated in this study. 79 lactoserum specimens obtained from right and/or left breasts from 42 Zambian women as well as lactosera and cell pellets from 40 milk samples collected from right and left breasts among 20 Ugandan women were tested for HPV using the INNO-LiPA HPV Genotyping Extra II assay.RESULTS:
HPV DNA was detected in 9 (11.4%) lactoserum specimens collected from 8 (19.0%) Zambian women. Fourteen (17.5%) samples from 5 (25%) Ugandan women were positive for HPV detection. Differences in HPV type identification between the two breasts as well as between lactoserum and cell pellet were oberved. Overall, 13 (21.0%) of the 62 women included in this study had detectable HPV DNA in their breast milk, representing 11 HPV types, including high-risk, probable high-risk and low-risk types.CONCLUSION:
This study confirms that HPV can be frequently detected in breast milk in HIV-infected women. Further studies are needed to understand the way by which maternal milk can shed HPV.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Papillomaviridae
/
DNA Viral
/
Eliminação de Partículas Virais
/
Infecções por Papillomavirus
/
Leite Humano
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article