Activating the PGC-1<i>&#945;</i>/TERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link.

Zhang, Yukun; Wang, Changyuan; Jin, Yue; Yang, Qining; Meng, Qiang; Liu, Qi; Dai, Yongguo; Cai, Lifei; Liu, Zhihao; Liu, Kexin; Sun, Huijun

Activating the PGC-1α/TERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link.

Zhang, Yukun; Wang, Changyuan; Jin, Yue; Yang, Qining; Meng, Qiang; Liu, Qi; Dai, Yongguo; Cai, Lifei; Liu, Zhihao; Liu, Kexin; Sun, Huijun.

Afiliação

Zhang Y; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China.
Wang C; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China.
Jin Y; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China.
Yang Q; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China.
Meng Q; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China.
Liu Q; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China.
Dai Y; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China.
Cai L; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China.
Liu Z; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China.
Liu K; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China.
Sun H; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China.

Oxid Med Cell Longev ; 2018: 2876350, 2018.

Article em En | MEDLINE | ID: mdl-30046372

Assuntos

Glucosídeos Iridoides/farmacologia; Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Telomerase/metabolismo; Telômero/efeitos dos fármacos; Telômero/metabolismo; Animais; Aterosclerose/tratamento farmacológico; Aterosclerose/metabolismo; Western Blotting; Linhagem Celular; Sobrevivência Celular/efeitos dos fármacos; Ensaio Cometa; Dano ao DNA/efeitos dos fármacos; Dano ao DNA/genética; Humanos; Imuno-Histoquímica; Marcação In Situ das Extremidades Cortadas; Glucosídeos Iridoides/uso terapêutico; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/metabolismo; Estresse Oxidativo/genética; Estresse Oxidativo/fisiologia; Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/genética; Células THP-1; Telomerase/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Telômero / Espécies Reativas de Oxigênio / Telomerase / Glucosídeos Iridoides / Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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