Modeling of fusion inhibitor treatment of RSV in African green monkeys.
J Theor Biol
; 456: 62-73, 2018 11 07.
Article
em En
| MEDLINE
| ID: mdl-30048719
ABSTRACT
Respiratory syncytial virus (RSV) is a respiratory infection that can cause serious illness, particularly in infants. In this study, we test four different model implementations for the effect of a fusion inhibitor, including one model that combines different drug effects, by fitting the models to data from a study of TMC353121 in African green monkeys. We use mathematical modeling to estimate the drug efficacy parameters, εmax, the maximum efficacy of the drug, and EC50, the drug concentration needed to achieve half the maximum effect. We find that if TMC353121 is having multiple effects on viral kinetics, more detailed data, using different treatment delays, is needed to detect this effect.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Vírus Sinciciais Respiratórios
/
Benzimidazóis
/
Infecções por Vírus Respiratório Sincicial
/
Inibidores de Proteínas Virais de Fusão
/
Modelos Biológicos
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article