Highly selective N-glucuronidation of four piperazine-containing drugs by UDP-glucuronosyltransferase 2B10.

Lu, Danyi; Dong, Dong; Wu, Baojian

Lu, Danyi; Dong, Dong; Wu, Baojian.

Afiliação

Lu D; a Research Center for Biopharmaceutics and Pharmacokinetics, College of Pharmacy , Jinan University , Guangzhou , China.
Dong D; b Shenzhen Key Laboratory for Molecular Biology of Neural Development, Guangdong Key Laboratory of Nanomedicine , Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , Shenzhen , China.
Wu B; c Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou , China.

Expert Opin Drug Metab Toxicol ; 14(9): 989-998, 2018 Sep.

Article em En | MEDLINE | ID: mdl-30049229

Assuntos

Glucuronídeos; Glucuronosiltransferase/metabolismo; Microssomos Hepáticos/metabolismo; Piperazinas/farmacocinética; Animais; Cães; Feminino; Cobaias; Humanos; Macaca fascicularis; Masculino; Camundongos; Microssomos Hepáticos/enzimologia; Coelhos; Ratos; Especificidade da Espécie

Palavras-chave

N-glucuronidation; UGT2B10; antihistamines; species differences; tetracyclic antidepressants

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperazinas / Microssomos Hepáticos / Glucuronosiltransferase / Glucuronídeos Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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