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Mediation analysis reveals common mechanisms of RUNX1 point mutations and RUNX1/RUNX1T1 fusions influencing survival of patients with acute myeloid leukemia.
Hornung, Roman; Jurinovic, Vindi; Batcha, Aarif M N; Bamopoulos, Stefanos A; Rothenberg-Thurley, Maja; Amler, Susanne; Sauerland, Maria Cristina; Berdel, Wolfgang E; Wörmann, Bernhard J; Bohlander, Stefan K; Braess, Jan; Hiddemann, Wolfgang; Lehmann, Sören; Mareschal, Sylvain; Spiekermann, Karsten; Metzeler, Klaus H; Herold, Tobias; Boulesteix, Anne-Laure.
Afiliação
  • Hornung R; Institute for Medical Information Processing, Biometry and Epidemiology, LMU Munich, Munich, Germany. hornung@med.uni-muenchen.de.
  • Jurinovic V; Institute for Medical Information Processing, Biometry and Epidemiology, LMU Munich, Munich, Germany.
  • Batcha AMN; Institute for Medical Information Processing, Biometry and Epidemiology, LMU Munich, Munich, Germany.
  • Bamopoulos SA; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany.
  • Rothenberg-Thurley M; German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Amler S; Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.
  • Sauerland MC; Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.
  • Berdel WE; Institute of Biostatistics and Clinical Research, University of Muenster, Muenster, Germany.
  • Wörmann BJ; Institute of Biostatistics and Clinical Research, University of Muenster, Muenster, Germany.
  • Bohlander SK; Department of Medicine A, Hematology and Oncology, University of Muenster, Muenster, Germany.
  • Braess J; German Society of Hematology and Oncology, Berlin, Germany.
  • Hiddemann W; Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.
  • Lehmann S; Department of Oncology and Hematology, Hospital Barmherzige Brüder, Regensburg, Germany.
  • Mareschal S; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany.
  • Spiekermann K; German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Metzeler KH; Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.
  • Herold T; Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden.
  • Boulesteix AL; Department of Medicine, Karolinska Institute, Stockholm, Sweden.
Sci Rep ; 8(1): 11293, 2018 07 26.
Article em En | MEDLINE | ID: mdl-30050054
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Mutação Puntual / Subunidade alfa 2 de Fator de Ligação ao Core / Fusão Gênica / Proteína 1 Parceira de Translocação de RUNX1 Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Mutação Puntual / Subunidade alfa 2 de Fator de Ligação ao Core / Fusão Gênica / Proteína 1 Parceira de Translocação de RUNX1 Idioma: En Ano de publicação: 2018 Tipo de documento: Article