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A bivalent compound targeting CCR5 and the mu opioid receptor treats inflammatory arthritis pain in mice without inducing pharmacologic tolerance.
Dutta, Raini; Lunzer, Mary M; Auger, Jennifer L; Akgün, Eyup; Portoghese, Philip S; Binstadt, Bryce A.
Afiliação
  • Dutta R; Department of Pediatrics and Center for Immunology, University of Minnesota, 2-114 Wallin Medical Biosciences Building, 2101 6th Street SE, Minneapolis, MN, 55414, USA.
  • Lunzer MM; Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
  • Auger JL; Department of Pediatrics and Center for Immunology, University of Minnesota, 2-114 Wallin Medical Biosciences Building, 2101 6th Street SE, Minneapolis, MN, 55414, USA.
  • Akgün E; Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
  • Portoghese PS; Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
  • Binstadt BA; Department of Pediatrics and Center for Immunology, University of Minnesota, 2-114 Wallin Medical Biosciences Building, 2101 6th Street SE, Minneapolis, MN, 55414, USA. binstadt@umn.edu.
Arthritis Res Ther ; 20(1): 154, 2018 07 27.
Article em En | MEDLINE | ID: mdl-30053832
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor / Piperidinas / Artrite Experimental / Artrite Reumatoide / Receptores Opioides mu / Receptores CCR5 / Analgésicos / Isoquinolinas Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor / Piperidinas / Artrite Experimental / Artrite Reumatoide / Receptores Opioides mu / Receptores CCR5 / Analgésicos / Isoquinolinas Idioma: En Ano de publicação: 2018 Tipo de documento: Article