High-performance electrochemical biosensor for nonenzymatic H2O2 sensing based on Au@C-Co3O4 heterostructures.
Biosens Bioelectron
; 118: 36-43, 2018 Oct 30.
Article
em En
| MEDLINE
| ID: mdl-30055418
ABSTRACT
An ingenious and viable method for preparing heterogeneous Co3O4 dodecahedrons that contain carbon and encapsulated Au nanoparticles (Au@C-Co3O4) was proposed via pyrolysis of Au nanoparticle-encapsulated zeolitic imidazolate framework-67 (Au@ZIF-67). The obtained Au@C-Co3O4 possessed hierarchically porous structure, abundant active sites, excellent conductivity, and durability, all of which can significantly improve the analysis performance of the biosensor. Meanwhile, the fabricated electrode based on the porous Au@C-Co3O4 showed remarkable electrocatalytic performance towards H2O2 with a limit of detection of 19â¯nM and ultra-high sensitivity of 7553 µA mM-1 cm-2, even when the Au content in the composite was as low as 0.85â¯wt%. This novel biosensor was successfully used to monitor H2O2 concentration released from living cells, and the results can be used to identify cancer cells, thus advancing the use of transition metal oxides in the field of biosensing.
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Base de dados:
MEDLINE
Assunto principal:
Técnicas Biossensoriais
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Cobalto
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Técnicas Eletroquímicas
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Ouro
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Peróxido de Hidrogênio
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article