Prognostic and Clinicopathological Value of PINX1 in Various Human Tumors: A Meta-Analysis.
Biomed Res Int
; 2018: 4621015, 2018.
Article
em En
| MEDLINE
| ID: mdl-30079348
ABSTRACT
PINX1 (Pin2/TRF1 interacting protein X1, an intrinsic telomerase inhibitor and putative tumor suppressor gene) may represent a novel prognostic tumor biomarker. However, the results of previous studies are inconsistent and the prognostic value of PINX1 remains controversial. Therefore, we conducted a meta-analysis to determine whether PINX1 expression is associated with overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), recurrence-free survival (RFS), and clinicopathological characteristics in patients with malignant tumors. A systematic search was performed in the PubMed, Web of Science, and Embase databases in April 2018. Quality assessment was performed according to the modified Newcastle-Ottawa Scale. Pooled odds ratios (ORs) and hazard ratios (HRs) with 95.0% confidence intervals (CIs) were calculated to determine the relationship between PINX1 expression and OS, DSS, DFS/RFS, and clinicopathological characteristics. Due to the heterogeneity across the included studies, subgroup and sensitivity analyses were performed. Fixed-effects models were used when the heterogeneity was not significant and random-effects models were used when the heterogeneity was significant. Fourteen studies of 16 cohorts including 2,624 patients were enrolled. Low PINX1 expression was associated with poor OS (HR 1.51, 95.0% CI 1.03-2.20; P = 0.035) and DFS/RFS (HR 1.78, 95.0% CI 1.28-2.47; P = 0.001) but not DSS (HR 0.80, 95.0% CI 0.38-1.67; P = 0.548). Low PINX1 expression was also associated with lymphatic invasion (OR 2.23, 95.0% CI 1.35-3.70; P = 0.002) and advanced tumor-node-metastasis stage (OR 2.43, 95.0% CI 1.29-4.57; P = 0.006). No significant associations were observed between low PINX1 expression and sex, depth of invasion, grade of differentiation, and distant metastasis. Low PINX1 expression was associated with poor OS and DFS/RFS and lymphatic invasion and advanced tumor-node-metastasis stage, suggesting that PINX1 expression may be a useful predictor of prognosis in patients with malignant tumors.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Supressoras de Tumor
/
Neoplasias
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article