Ruthenium(ii)-catalyzed selective C-H difluoroalkylation of aniline derivatives with pyrimidyl auxiliaries.
Chem Commun (Camb)
; 54(68): 9541-9544, 2018 Aug 21.
Article
em En
| MEDLINE
| ID: mdl-30094417
ABSTRACT
A ruthenium-catalyzed alternative para- and meta-difluoroalkylation of anilines is herein reported. The reaction tolerates a broad range of aniline derivatives and provides a convenient approach for accessing the corresponding para/meta-selective difluoroalkylated products. Mechanism studies demonstrated that the initial CAr-H and N-H cycloruthenation is the pivotal step in achieving remote C-H difluoroacetylation.
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MEDLINE
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En
Ano de publicação:
2018
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Article