Sialidase down-regulation reduces non-HDL cholesterol, inhibits leukocyte transmigration, and attenuates atherosclerosis in ApoE knockout mice.

White, Elizabeth J; Gyulay, Gabriel; Lhoták, Sárka; Szewczyk, Magdalena M; Chong, Taryne; Fuller, Mark T; Dadoo, Omid; Fox-Robichaud, Alison E; Austin, Richard C; Trigatti, Bernardo L; Igdoura, Suleiman A

White, Elizabeth J; Gyulay, Gabriel; Lhoták, Sárka; Szewczyk, Magdalena M; Chong, Taryne; Fuller, Mark T; Dadoo, Omid; Fox-Robichaud, Alison E; Austin, Richard C; Trigatti, Bernardo L; Igdoura, Suleiman A.

Afiliação

White EJ; From the Departments of Biology.
Gyulay G; From the Departments of Biology.
Lhoták S; the Department of Medicine, Division of Nephrology, McMaster University, St. Joseph's Healthcare and Hamilton Centre for Kidney Research, Hamilton, Ontario L8N 4A6, Canada.
Szewczyk MM; From the Departments of Biology.
Chong T; From the Departments of Biology.
Fuller MT; Biochemistry and Biomedical Sciences.
Dadoo O; Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario L8S 4K1 and.
Fox-Robichaud AE; Biochemistry and Biomedical Sciences.
Austin RC; Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario L8S 4K1 and.
Trigatti BL; the Department of Medicine, Division of Nephrology, McMaster University, St. Joseph's Healthcare and Hamilton Centre for Kidney Research, Hamilton, Ontario L8N 4A6, Canada.
Igdoura SA; Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario L8S 4K1 and.

J Biol Chem ; 293(38): 14689-14706, 2018 09 21.

Article em En | MEDLINE | ID: mdl-30097518

Assuntos

Apolipoproteínas E/genética; Aterosclerose/metabolismo; Quimiotaxia de Leucócito; LDL-Colesterol/sangue; VLDL-Colesterol/sangue; Regulação para Baixo; Neuraminidase/metabolismo; Animais; Aorta/patologia; LDL-Colesterol/metabolismo; VLDL-Colesterol/metabolismo; Ácido Hialurônico/metabolismo; Fígado/metabolismo; Macrófagos/citologia; Masculino; Camundongos; Camundongos Knockout para ApoE; Músculo Liso Vascular/citologia; Selectina-P/metabolismo; Linfócitos T/citologia; Triglicerídeos/metabolismo

Palavras-chave

Hyaluronic acid; P-selectin; apolipoprotein E (ApoE); atherosclerosis; bone marrow; gene knockout; glycosylation inhibitor; lipoprotein metabolism; monocyte; sialic acid; sialidase; transplantation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apolipoproteínas E / VLDL-Colesterol / Regulação para Baixo / Quimiotaxia de Leucócito / Aterosclerose / LDL-Colesterol / Neuraminidase Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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