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Admission heart rate and in-hospital course of patients with Takotsubo syndrome.
Arcari, Luca; Limite, Luca Rosario; Cacciotti, Luca; Sclafani, Matteo; Russo, Domitilla; Passaseo, Ilaria; Marazzi, Giuseppe; Ansalone, Gerardo; Volpe, Massimo; Autore, Camillo; Musumeci, Maria Beatrice.
Afiliação
  • Arcari L; Cardiology, Clinical and Molecular Medicine Department, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy. Electronic address: luca_arcari@outlook.it.
  • Limite LR; Cardiology, Clinical and Molecular Medicine Department, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.
  • Cacciotti L; Institute of Cardiology, Madre Giuseppina Vannini Hospital, Rome, Italy.
  • Sclafani M; Cardiology, Clinical and Molecular Medicine Department, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.
  • Russo D; Cardiology, Clinical and Molecular Medicine Department, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.
  • Passaseo I; Institute of Cardiology, Madre Giuseppina Vannini Hospital, Rome, Italy.
  • Marazzi G; San Raffaele, Rome, Italy.
  • Ansalone G; Institute of Cardiology, Madre Giuseppina Vannini Hospital, Rome, Italy.
  • Volpe M; Cardiology, Clinical and Molecular Medicine Department, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy; IRCCS Neuromed, Pozzilli, IS, Italy.
  • Autore C; Cardiology, Clinical and Molecular Medicine Department, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.
  • Musumeci MB; Cardiology, Clinical and Molecular Medicine Department, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.
Int J Cardiol ; 273: 15-21, 2018 Dec 15.
Article em En | MEDLINE | ID: mdl-30100222
BACKGROUND: In-hospital course of patients with Takotsubo syndrome (TS) is quite heterogeneous and life-threatening complications are not uncommon in the acute phase. The role of heart rate (HR) as a predictor of prognosis has not been sufficiently investigated in this setting. The study aims to assess the impact of HR at presentation on in-hospital course of patients with TS. METHODS: The study population included 221 patients with TS enrolled in a multicentric registry. HR at admission was evaluated on the first electrocardiogram. According to tertile distribution of HR at presentation, 3 groups were identified: Group A (HR ≤ 76 beats per minute (bpm), n = 76), Group B (HR 77-95 bpm, n = 74) and Group C (HR > 95 bpm, n = 71). Acute in-hospital complications were defined as occurrence of severe pump failure and major arrhythmias. RESULTS: 32 (14.4%) patients experienced complicated in-hospital course. HR on admission was significantly higher (108 bpm vs. 85 bpm; p < 0.001) and ejection fraction (EF) lower (35% vs. 40%; p = 0.009) in patients with complications than in those without. Patients in Group C experienced a 5-fold higher rate of complications compared to group A and B. After multivariate analysis, higher HR (odds ratio 1.34 per 10 bpm increase, 95% confidence interval (CI) 1.12-1.59; p = 0.001) and lower EF (odds ratio 1.24 per 5% decrease, 95% CI 1.01-1.54; p = 0.049) remained independently associated with a worse outcome. CONCLUSION: In a large population with TS, high HR on admission independently predicted complicated in-hospital course.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Admissão do Paciente / Cardiomiopatia de Takotsubo / Frequência Cardíaca / Tempo de Internação Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Admissão do Paciente / Cardiomiopatia de Takotsubo / Frequência Cardíaca / Tempo de Internação Idioma: En Ano de publicação: 2018 Tipo de documento: Article