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Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease.
Lim, Ji Woong; Kim, Seok Kyu; Choi, Seo Yun; Kim, Dong Hoi; Gadhe, Changdev G; Lee, Hae Nim; Kim, Hyo-Ji; Kim, Jina; Cho, Sung Jin; Hwang, Hayoung; Seong, Jihye; Jeong, Kyu-Sung; Lee, Jae Yeol; Lim, Sang Min; Lee, Jae Wook; Pae, Ae Nim.
Afiliação
  • Lim JW; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, 02447, Republic of Korea.
  • Kim SK; Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University, Seoul, 02447, Republic of Korea.
  • Choi SY; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea; Department of Chemistry, Yonsei University, Seoul, 03722, Republic of Korea.
  • Kim DH; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.
  • Gadhe CG; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.
  • Lee HN; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.
  • Kim HJ; New Drug Development Center, Daegu Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu, 41061, Republic of Korea.
  • Kim J; New Drug Development Center, Daegu Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu, 41061, Republic of Korea.
  • Cho SJ; New Drug Development Center, Daegu Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu, 41061, Republic of Korea.
  • Hwang H; New Drug Development Center, Daegu Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu, 41061, Republic of Korea.
  • Seong J; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, 02447, Republic of Korea; Division of Bio-Medical Scien
  • Jeong KS; Department of Chemistry, Yonsei University, Seoul, 03722, Republic of Korea.
  • Lee JY; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, 02447, Republic of Korea; Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University, Seoul, 02447, Republic of Korea. Electronic address: ljy@khu.ac.kr.
  • Lim SM; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea; Division of Bio-Medical Science and Technology, Korea University of Science and Technology, Daejon, 34113, Republic of Korea. Electronic addre
  • Lee JW; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea; Division of Bio-Medical Science and Technology, Korea University of Science and Technology, Daejon, 34113, Republic of Korea. Electronic addre
  • Pae AN; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, 02447, Republic of Korea; Division of Bio-Medical Scien
Eur J Med Chem ; 157: 405-422, 2018 Sep 05.
Article em En | MEDLINE | ID: mdl-30103190
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Piridinas / Inibidores Enzimáticos / Doença de Alzheimer / Fosfatidilinositol-3,4,5-Trifosfato 5-Fosfatases Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Piridinas / Inibidores Enzimáticos / Doença de Alzheimer / Fosfatidilinositol-3,4,5-Trifosfato 5-Fosfatases Idioma: En Ano de publicação: 2018 Tipo de documento: Article