Turning off Bacillus cereus quorum sensing system with peptidic analogs.
Chem Commun (Camb)
; 54(70): 9777-9780, 2018 Aug 28.
Article
em En
| MEDLINE
| ID: mdl-30105347
ABSTRACT
We explored quenching of the PlcR-PapR quorum-sensing system in Bacillus cereus. We generated PapR7-peptidic derivatives that inhibit this system and thus the production of virulence factors, reflected by a loss in hemolytic activity, without affecting bacterial growth. To our knowledge, these peptides represent the first potent synthetic inhibitors of quorum-sensing in B. cereus.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
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Bacillus cereus
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Proteínas de Bactérias
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Regulon
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Percepção de Quorum
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article