Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte Proliferation.
Cell Mol Gastroenterol Hepatol
; 6(3): 239-255, 2018.
Article
em En
| MEDLINE
| ID: mdl-30109252
Palavras-chave
2D, 2-dimensional; BrdU, bromodeoxyuridine; C/EBP, CCAAT/enhancer binding protein; CUGBP1, CUG triplet repeat binding protein 1; Cancer; Co-IP, co-immunoprecipitation; DEN, diethylnitrosamine; FXR, farnesoid X receptor; GLKO, Gankyrin liver-specific knock-out; Gank, Gankyrin; HCC, hepatocellular carcinoma; HNF4α, hepatocyte nuclear factor 4α; LKO, liver-specific knock-out; Liver; Opn, osteopontin; PCNA, proliferating cell nuclear antigen; PH, partial hepatectomy; Progenitor Cells; Proliferation; RT-PCR, reverse-transcriptase polymerase chain reaction; Rb, retinoblastoma; TSP, tumor-suppressor protein; Tumor-Suppressor Proteins; UPS, ubiquitin proteasome system; WT, wild-type; cDNA, complementary DNA; mRNA, messenger RNA
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Hepatoblastoma
/
Carcinoma Hepatocelular
/
Hepatócitos
/
Proteínas Supressoras de Tumor
/
Neoplasias Hepáticas
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article