Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte Proliferation.

D'Souza, Amber M; Jiang, Yanjun; Cast, Ashley; Valanejad, Leila; Wright, Mary; Lewis, Kyle; Kumbaji, Meenasri; Shah, Sheeniza; Smithrud, David; Karns, Rebekah; Shin, Soona; Timchenko, Nikolai

D'Souza, Amber M; Jiang, Yanjun; Cast, Ashley; Valanejad, Leila; Wright, Mary; Lewis, Kyle; Kumbaji, Meenasri; Shah, Sheeniza; Smithrud, David; Karns, Rebekah; Shin, Soona; Timchenko, Nikolai.

Afiliação

D'Souza AM; Department of Oncology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Jiang Y; Huffington Center on Aging, Baylor College of Medicine, Houston, Texas.
Cast A; Department of Surgery, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Valanejad L; Department of Surgery, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Wright M; Department of Surgery, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Lewis K; Department of Surgery, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Kumbaji M; Department of Surgery, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Shah S; Department of Chemistry, University of Cincinnati, Cincinnati, Ohio.
Smithrud D; Department of Chemistry, University of Cincinnati, Cincinnati, Ohio.
Karns R; Department of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Shin S; Department of Surgery, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Timchenko N; Department of Surgery, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Cell Mol Gastroenterol Hepatol ; 6(3): 239-255, 2018.

Article em En | MEDLINE | ID: mdl-30109252

Assuntos

Carcinoma Hepatocelular/patologia; Hepatoblastoma/patologia; Hepatócitos/patologia; Neoplasias Hepáticas/patologia; Fatores de Transcrição/metabolismo; Proteínas Supressoras de Tumor/metabolismo; Animais; Benzenossulfonatos/farmacologia; Tetracloreto de Carbono/farmacologia; Carcinoma Hepatocelular/metabolismo; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Hepatoblastoma/metabolismo; Hepatócitos/efeitos dos fármacos; Humanos; Neoplasias Hepáticas/metabolismo; Masculino; Camundongos; Camundongos Knockout; Fatores de Transcrição/genética; Triazóis/farmacologia

Palavras-chave

2D, 2-dimensional; BrdU, bromodeoxyuridine; C/EBP, CCAAT/enhancer binding protein; CUGBP1, CUG triplet repeat binding protein 1; Cancer; Co-IP, co-immunoprecipitation; DEN, diethylnitrosamine; FXR, farnesoid X receptor; GLKO, Gankyrin liver-specific knock-out; Gank, Gankyrin; HCC, hepatocellular carcinoma; HNF4α, hepatocyte nuclear factor 4α; LKO, liver-specific knock-out; Liver; Opn, osteopontin; PCNA, proliferating cell nuclear antigen; PH, partial hepatectomy; Progenitor Cells; Proliferation; RT-PCR, reverse-transcriptase polymerase chain reaction; Rb, retinoblastoma; TSP, tumor-suppressor protein; Tumor-Suppressor Proteins; UPS, ubiquitin proteasome system; WT, wild-type; cDNA, complementary DNA; mRNA, messenger RNA

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Hepatoblastoma / Carcinoma Hepatocelular / Hepatócitos / Proteínas Supressoras de Tumor / Neoplasias Hepáticas Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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