Total Fluid Intake and the Risk of Recurrence in Patients With Non-Muscle Invasive Bladder Cancer: A Prospective Cohort Study.

Jochems, Sylvia H J; van Osch, Frits H M; Reulen, Raoul C; van Hensbergen, Mitch; Nekeman, Duncan; Pirrie, Sarah J; Wesselius, Anke; van Schooten, Frederik J; James, Nicholas D; Wallace, D Michael A; Bryan, Richard T; Cheng, K K; Zeegers, Maurice P

Jochems, Sylvia H J; van Osch, Frits H M; Reulen, Raoul C; van Hensbergen, Mitch; Nekeman, Duncan; Pirrie, Sarah J; Wesselius, Anke; van Schooten, Frederik J; James, Nicholas D; Wallace, D Michael A; Bryan, Richard T; Cheng, K K; Zeegers, Maurice P.

Afiliação

Jochems SHJ; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
van Osch FHM; School for Nutrition and Translational Research in Metabolism, Maastricht University, The Netherlands.
Reulen RC; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
van Hensbergen M; School for Nutrition and Translational Research in Metabolism, Maastricht University, The Netherlands.
Nekeman D; Department of Public Health, Epidemiology and Biostatistics, institute of Applied Health Research, University of Birmingham, UK.
Pirrie SJ; School for Nutrition and Translational Research in Metabolism, Maastricht University, The Netherlands.
Wesselius A; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
van Schooten FJ; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
James ND; School for Nutrition and Translational Research in Metabolism, Maastricht University, The Netherlands.
Wallace DMA; School for Nutrition and Translational Research in Metabolism, Maastricht University, The Netherlands.
Bryan RT; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Cheng KK; University Hospital Birmingham, NHS Foundation Trust, Birmingham, UK.
Zeegers MP; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.

Bladder Cancer ; 4(3): 303-310, 2018 Jul 30.

Article em En | MEDLINE | ID: mdl-30112441

ABSTRACT

ABSTRACT

OBJECTIVES:

To investigate the role of fluid intake from beverages before and after a diagnosis of bladder cancer in relation to the risk of developing bladder cancer recurrence. STUDY

DESIGN:

Prospective cohort study.

METHODS:

716 patients with non-muscle invasive bladder cancer (NMIBC), who received transurethral resection of a primary bladder tumour (TURBT) and completed self-administrated questionnaires on usual fluid intake from beverages at time of diagnosis (over the year before diagnosis) and during follow-up (over the year after diagnosis), were included. Multivariable Cox regression was used to calculate hazard ratios and 95% confidence intervals of developing recurrent bladder cancer in relation to the intake of total fluid, total alcohol, and individual beverages.

RESULTS:

During 2,025 person-years of follow-up, 238 (33%) of the included 716 NMIBC patients developed one or more recurrences of bladder cancer. Total fluid intake before diagnosis was not associated with a first recurrence of bladder cancer when comparing the highest and lowest intake group (HR = 0.98, 95% C.I. 0.70-1.38, p = 0.91). Comparable results were obtained for total fluid intake pre-diagnosis and the risk of developing multiple recurrences of bladder cancer (HR = 1.01, 95% C.I. 0.87-1.19, p = 0.85). A total of 379 of the 716 patients reported on usual fluid intake within 1 year of diagnosis. No significant associations between total fluid intake 1 year after diagnosis and a first recurrence of bladder cancer were found when comparing the highest and lowest intake group (HR = 0.91; 95% C.I. 0.60-1.37, p = 0.65) or with multiple recurrences of bladder cancer (HR = 1.06; 95% C.I. 0.89-1.26, p = 0.54). In addition, total alcohol intake and individual beverages were not associated with bladder cancer recurrence.