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Intron retention is a source of neoepitopes in cancer.
Smart, Alicia C; Margolis, Claire A; Pimentel, Harold; He, Meng Xiao; Miao, Diana; Adeegbe, Dennis; Fugmann, Tim; Wong, Kwok-Kin; Van Allen, Eliezer M.
Afiliação
  • Smart AC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Margolis CA; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Pimentel H; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • He MX; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Miao D; Department of Genetics and Biology, Stanford University, Stanford, California, USA.
  • Adeegbe D; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Fugmann T; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Wong KK; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Van Allen EM; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Nat Biotechnol ; 36(11): 1056-1058, 2018 12.
Article em En | MEDLINE | ID: mdl-30114007
ABSTRACT
We present an in silico approach to identifying neoepitopes derived from intron retention events in tumor transcriptomes. Using mass spectrometry immunopeptidome analysis, we show that retained intron neoepitopes are processed and presented on MHC I on the surface of cancer cell lines. RNA-derived neoepitopes should be considered for prospective personalized cancer vaccine development.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Simulação por Computador / Íntrons / Modelos Genéticos / Epitopos / Neoplasias Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Simulação por Computador / Íntrons / Modelos Genéticos / Epitopos / Neoplasias Idioma: En Ano de publicação: 2018 Tipo de documento: Article