Furamidine Rescues Myotonic Dystrophy Type I Associated Mis-Splicing through Multiple Mechanisms.

Jenquin, Jana R; Coonrod, Leslie A; Silverglate, Quinn A; Pellitier, Natalie A; Hale, Melissa A; Xia, Guangbin; Nakamori, Masayuki; Berglund, J Andrew

Jenquin, Jana R; Coonrod, Leslie A; Silverglate, Quinn A; Pellitier, Natalie A; Hale, Melissa A; Xia, Guangbin; Nakamori, Masayuki; Berglund, J Andrew.

Afiliação

Jenquin JR; Department of Biochemistry & Molecular Biology, Center for NeuroGenetics , College of Medicine, University of Florida , Gainesville , Florida 32610 , United States.
Coonrod LA; Phil and Penny Knight Campus for Accelerating Scientific Impact , University of Oregon , Eugene , Oregon 97403 , United States.
Silverglate QA; Department of Biochemistry & Molecular Biology, Center for NeuroGenetics , College of Medicine, University of Florida , Gainesville , Florida 32610 , United States.
Pellitier NA; Department of Biology , University of Oregon , Eugene , Oregon 97403 , United States.
Hale MA; Department of Biochemistry & Molecular Biology, Center for NeuroGenetics , College of Medicine, University of Florida , Gainesville , Florida 32610 , United States.
Xia G; Department of Neurology and Neuroscience , University of New Mexico School of Medicine , Albuquerque , New Mexico 87131 , United States.
Nakamori M; Department of Neurology , Osaka University Graduate School of Medicine , Osaka 565-0871 , Japan.
Berglund JA; Department of Biochemistry & Molecular Biology, Center for NeuroGenetics , College of Medicine, University of Florida , Gainesville , Florida 32610 , United States.

ACS Chem Biol ; 13(9): 2708-2718, 2018 09 21.

Article em En | MEDLINE | ID: mdl-30118588

Assuntos

Benzamidinas/uso terapêutico; Distrofia Miotônica/tratamento farmacológico; Distrofia Miotônica/genética; Splicing de RNA/efeitos dos fármacos; Animais; Antifúngicos/farmacologia; Antifúngicos/uso terapêutico; Benzamidinas/farmacologia; Células Cultivadas; Modelos Animais de Doenças; Humanos; Camundongos; Fibras Musculares Esqueléticas/efeitos dos fármacos; Fibras Musculares Esqueléticas/metabolismo; Fibras Musculares Esqueléticas/patologia; Distrofia Miotônica/metabolismo; Distrofia Miotônica/patologia; RNA/genética; RNA/metabolismo; Proteínas de Ligação a RNA/genética; Proteínas de Ligação a RNA/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzamidinas / Splicing de RNA / Distrofia Miotônica Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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