CAR-T Cell Therapy for Acute Lymphoblastic Leukemia: Transforming the Treatment of Relapsed and Refractory Disease.
Curr Hematol Malig Rep
; 13(5): 396-406, 2018 10.
Article
em En
| MEDLINE
| ID: mdl-30120708
ABSTRACT
PURPOSE OF REVIEW Genetically engineered T cells expressing a chimeric antigen receptor (CAR-T) targeting specific antigens present on acute lymphoblastic leukemia (ALL) blasts have generated promising results in children and adults with relapsed and refractory disease. We review the current evidence for CAR-T cell therapy in ALL, associated toxicities, and efforts to improve durable response to therapy. RECENT FINDINGS:
CD19-directed CAR-T cells have recently been approved by the FDA for use in children and young adults with ALL and in adults with diffuse large B cell lymphoma (DLBCL) in the relapsed/refractory setting. CD22-directed CAR-T cells have shown efficacy against leukemia as well in a recent clinical trial, representing the first alternative CAR target to approach comparable efficacy to CD19 CAR-T cells. Standardization of toxicity grading and management, strategies to combat significant relapse rates after CAR-T therapy, and applicability of CAR-T cells to treat central nervous system (CNS) disease remain challenges in the field and represent priorities for continued research. CAR-T cells are a feasible, effective, and rapidly evolving therapy for patients with relapsed and refractory B cell malignancies.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Imunoterapia Adotiva
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Linfoma Difuso de Grandes Células B
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Neoplasias do Sistema Nervoso Central
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Leucemia-Linfoma Linfoblástico de Células Precursoras
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Receptores de Antígenos Quiméricos
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article