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The novel peripherally active cannabinoid type 1 and serotonin type 3 receptor agonist AM9405 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome.
Salaga, Maciej; Binienda, Agata; Tichkule, Ritesh B; Thakur, Ganesh A; Makriyannis, Alexandros; Storr, Martin; Fichna, Jakub.
Afiliação
  • Salaga M; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
  • Binienda A; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
  • Tichkule RB; Center for Drug Discovery, Department of Pharmaceutical Sciences, Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, United States.
  • Thakur GA; Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, United States.
  • Makriyannis A; Center for Drug Discovery, Department of Pharmaceutical Sciences, Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, United States.
  • Storr M; Center of Endoscopy, Starnberg, Germany and Department of Medicine 2, Ludwig-Maximilian University Munich, Munich, Germany.
  • Fichna J; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland. Electronic address: jakub.fichna@umed.lodz.pl.
Eur J Pharmacol ; 836: 34-43, 2018 Oct 05.
Article em En | MEDLINE | ID: mdl-30121173
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor Abdominal / Síndrome do Intestino Irritável / Receptor CB1 de Canabinoide / Receptores 5-HT3 de Serotonina / Agonistas do Receptor 5-HT3 de Serotonina / Motilidade Gastrointestinal / Imidazóis Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor Abdominal / Síndrome do Intestino Irritável / Receptor CB1 de Canabinoide / Receptores 5-HT3 de Serotonina / Agonistas do Receptor 5-HT3 de Serotonina / Motilidade Gastrointestinal / Imidazóis Idioma: En Ano de publicação: 2018 Tipo de documento: Article