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CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation.
Cereijo, Rubén; Gavaldà-Navarro, Aleix; Cairó, Montserrat; Quesada-López, Tania; Villarroya, Joan; Morón-Ros, Samantha; Sánchez-Infantes, David; Peyrou, Marion; Iglesias, Roser; Mampel, Teresa; Turatsinze, Jean-Valery; Eizirik, Décio L; Giralt, Marta; Villarroya, Francesc.
Afiliação
  • Cereijo R; Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of the University of Barcelona, Barcelona, Catalonia, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain.
  • Gavaldà-Navarro A; Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of the University of Barcelona, Barcelona, Catalonia, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain.
  • Cairó M; Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of the University of Barcelona, Barcelona, Catalonia, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain.
  • Quesada-López T; Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of the University of Barcelona, Barcelona, Catalonia, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain.
  • Villarroya J; Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of the University of Barcelona, Barcelona, Catalonia, Spain; Institut de Recerca Hospital de la Santa Creu i Sant Pau, Barcelona, Catalonia, Spain.
  • Morón-Ros S; Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of the University of Barcelona, Barcelona, Catalonia, Spain.
  • Sánchez-Infantes D; Department of Endocrinology and Nutrition, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Barcelona, Catalonia, Spain.
  • Peyrou M; Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of the University of Barcelona, Barcelona, Catalonia, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain.
  • Iglesias R; Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of the University of Barcelona, Barcelona, Catalonia, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain.
  • Mampel T; Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of the University of Barcelona, Barcelona, Catalonia, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain.
  • Turatsinze JV; Laboratory of Experimental Medicine, ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.
  • Eizirik DL; Laboratory of Experimental Medicine, ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.
  • Giralt M; Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of the University of Barcelona, Barcelona, Catalonia, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain; Institut de Recerca Hospital Sant Joan de Déu, Barcelona, Catalonia, Spain.
  • Villarroya F; Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of the University of Barcelona, Barcelona, Catalonia, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain; Institut de Recerca Hospital Sant Joan de Déu, Barcelona, Catalonia, Spain. Electr
Cell Metab ; 28(5): 750-763.e6, 2018 11 06.
Article em En | MEDLINE | ID: mdl-30122557
ABSTRACT
The beneficial effects of brown adipose tissue (BAT) are attributed to its capacity to oxidize metabolites and produce heat, but recent data suggest that secretory properties of BAT may also be involved. Here, we identify the chemokine CXCL14 (C-X-C motif chemokine ligand-14) as a novel regulatory factor secreted by BAT in response to thermogenic activation. We found that the CXCL14 released by brown adipocytes recruited alternatively activated (M2) macrophages. Cxcl14-null mice exposed to cold showed impaired BAT activity and low recruitment of macrophages, mainly of the M2 phenotype, into BAT. CXCL14 promoted the browning of white fat and ameliorated glucose/insulin homeostasis in high-fat-diet-induced obese mice. Impairment of type 2 cytokine signaling, as seen in Stat6-null mice, blunts the action of CXCL14, promoting adipose tissue browning. We propose that active BAT is a source of CXCL14, which concertedly promotes adaptive thermogenesis via M2 macrophage recruitment, BAT activation, and the browning of white fat.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tecido Adiposo Marrom / Quimiocinas CXC / Termogênese / Obesidade Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tecido Adiposo Marrom / Quimiocinas CXC / Termogênese / Obesidade Idioma: En Ano de publicação: 2018 Tipo de documento: Article