LncRNA CRNDE is a biomarker for clinical progression and poor prognosis in clear cell renal cell carcinoma.
J Cell Biochem
; 119(12): 10406-10414, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-30129055
ABSTRACT
Colorectal neoplasia differentially expressed (CRNDE) served as an oncogenic long noncoding RNA (lncRNA) to be involved in the initialization and development of human cancers. However, the clinical significance and biological function of CRNDE in clear cell renal cell carcinoma (ccRCC) was not fully understood. In our study, we found CRNDE levels were increased in ccRCC tissue specimens and cell lines, and corrected with advanced clinical stage, large tumor size, lymph node metastasis, distant metastasis, and poor pathological grade in patients with ccRCC. Furthermore, levels of CRNDE were negatively correlated with overall survival of patients with ccRCC, and high-expression of CRNDE was an independent poor prognostic factor for patients with ccRCC. Moreover, loss-of-function and gain-of-function approaches showed CRNDE-enhanced ccRCC cell migration and invasion through modulating EMT-associated genes. In conclusion, CRNDE acts as an oncogenic lncRNA in ccRCC.
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Base de dados:
MEDLINE
Assunto principal:
Prognóstico
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Carcinoma de Células Renais
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Biomarcadores Tumorais
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RNA Longo não Codificante
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article