Crystal structures of pan-IDH inhibitor AG-881 in complex with mutant human IDH1 and IDH2.

Ma, Rui; Yun, Cai-Hong

Ma, Rui; Yun, Cai-Hong.

Afiliação

Ma R; Department of Biophysics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China; Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China; Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing 100191, China.
Yun CH; Department of Biophysics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China; Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China; Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing 100191, China. Electronic address: yunch@hsc.pku.edu.cn.

Biochem Biophys Res Commun ; 503(4): 2912-2917, 2018 09 18.

Article em En | MEDLINE | ID: mdl-30131249

Assuntos

Inibidores Enzimáticos/química; Isocitrato Desidrogenase/química; Proteínas Mutantes/química; Sítio Alostérico; Cristalografia por Raios X; Humanos; Concentração Inibidora 50; Isocitrato Desidrogenase/antagonistas & inibidores; Isocitrato Desidrogenase/genética; Mutação; Neoplasias/etiologia; Neoplasias/genética; Ligação Proteica; Conformação Proteica

Palavras-chave

AG-881; IDH1; IDH2; R132H; R140Q

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Proteínas Mutantes / Isocitrato Desidrogenase Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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