Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice.
Rev Soc Bras Med Trop
; 51(4): 546-549, 2018.
Article
em En
| MEDLINE
| ID: mdl-30133643
ABSTRACT
INTRODUCTION:
We evaluated IL-10, IL-2 and regulatory T cells (Treg), in response to ovalbumin (OA), in offspring from schistosomotic mouse mothers.METHODS:
We used animals born (BIM) or suckled (SIM) from infected mothers; and mice born/suckled from infected (BSIM) or non-infected mothers (CONTROL). After OA+adjuvant immunization, spleen cells were cultured, with or without OA, and doubly marked for cytometry.RESULTS:
BIM showed fewer CD4+/IL-2+ and more B220+/IL-10+ cells, whereas the SIM group showed increased Treg frequency. BSIM had fewer B220+/IL-10+ and Treg cells.CONCLUSIONS:
Separately, gestation or nursing induced immunosuppressive cells in infected mothers, but improved anti-OA immunity when combined.
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Base de dados:
MEDLINE
Assunto principal:
Esquistossomose mansoni
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Anticorpos Anti-Helmínticos
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Interleucina-2
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Interleucina-10
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Linfócitos T Reguladores
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Animais Lactentes
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article