An Augmented Negative Force-Frequency Relationship and Slowed Mechanical Restitution Are Associated With Increased Susceptibility to Drug-Induced Torsade de Pointes Arrhythmias in the Chronic Atrioventricular Block Dog.

Sprenkeler, David J; Bossu, Alexandre; Beekman, Jet D M; Schoenmakers, Marieke; Vos, Marc A

Sprenkeler, David J; Bossu, Alexandre; Beekman, Jet D M; Schoenmakers, Marieke; Vos, Marc A.

Afiliação

Sprenkeler DJ; Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands.
Bossu A; Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands.
Beekman JDM; Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands.
Schoenmakers M; Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands.
Vos MA; Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands.

Front Physiol ; 9: 1086, 2018.

Article em En | MEDLINE | ID: mdl-30135660

Palavras-chave

Torsade de Pointes; chronic AV-block dog; contractile remodeling; force-frequency relationship; mechanical restitution; post-extrasystolic potentiation

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article