CDKN2A Depletion Causes Aneuploidy and Enhances Cell Proliferation in Non-Immortalized Normal Human Cells.
Cancer Invest
; 36(6): 338-348, 2018.
Article
em En
| MEDLINE
| ID: mdl-30136875
ABSTRACT
Aneuploidy is a common feature of cancer cells and may contribute to cellular transformation and cancer development. In this study, we found that significant down-regulation of CDKN2A, CHEK2, CDCA8, TP53BP1, and CCNDBP1 led to chromosome imbalances in two diploid non-immortalized human cell lines; however, only CDKN2A inhibition enhanced cell proliferation and additionally up-regulated three cell cycle control genes CDCA8, AURKA, and CCND. These results confirm that CDKN2A is a tumor suppressor gene driving human cancer development by inducing cell aneuploidy and cell cycle up-regulation.
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MEDLINE
Assunto principal:
Transformação Celular Neoplásica
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Genes Supressores de Tumor
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Proliferação de Células
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Inibidor de Quinase Dependente de Ciclina p18
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article