Epigenetic age-predictor for mice based on three CpG sites.
Elife
; 72018 08 24.
Article
em En
| MEDLINE
| ID: mdl-30142075
ABSTRACT
Epigenetic clocks for mice were generated based on deep-sequencing analysis of the methylome. Here, we demonstrate that site-specific analysis of DNA methylation levels by pyrosequencing at only three CG dinucleotides (CpGs) in the genes Prima1, Hsf4, and Kcns1 facilitates precise estimation of chronological age in murine blood samples, too. DBA/2 mice revealed accelerated epigenetic aging as compared to C57BL6 mice, which is in line with their shorter life-expectancy. The three-CpG-predictor provides a simple and cost-effective biomarker to determine biological age in large intervention studies with mice.
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Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
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Ilhas de CpG
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Epigênese Genética
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article