New piperidine-based derivatives as sigma receptor ligands. Synthesis and pharmacological evaluation.
Bioorg Med Chem Lett
; 28(19): 3206-3209, 2018 10 15.
Article
em En
| MEDLINE
| ID: mdl-30143421
ABSTRACT
The sigma receptor (σR) family has been considered mysterious for a long time. In fact, the σ2R subtype has been cloned only recently, revealing its identity as TMEM97, a NPC1-binding protein involved in cholesterol biosynthesis and implicated in the pathogenesis of cancer and neurologic disorders. With the aim of developing new chemical entities gifted with σR affinity, herein we report the design and synthesis of new piperidine-based alkylacetamide derivatives with mixed affinity towards both σ1 and σ2R subtypes.
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Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Receptores sigma
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article