Applications of Powder X-Ray Diffraction in Small Molecule Pharmaceuticals: Achievements and Aspirations.
J Pharm Sci
; 107(12): 2969-2982, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-30145209
ABSTRACT
Since the discovery of X-ray diffraction and its potential to elucidate crystal symmetry, powder X-ray diffraction has found diverse applications in the field of pharmaceutical sciences. This review summarizes significant achievements of the technique during various stages of dosage form development. Improved understanding of the principle involved and development of automated hardware and reliable software have led to increased instrumental sensitivity and improved data analysis. These advances continue to expand the applications of powder X-ray diffraction to emerging research fields such as amorphous systems, mechanistic understanding of phase transformations, and "Quality by Design" in formulation development.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Difração de Raios X
/
Preparações Farmacêuticas
/
Difração de Pó
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article