Angiogenesis in pancreatic cancer: current research status and clinical implications.
Angiogenesis
; 22(1): 15-36, 2019 02.
Article
em En
| MEDLINE
| ID: mdl-30168025
ABSTRACT
Pancreatic cancer is one of the most lethal malignancies worldwide. Although the standard of care in pancreatic cancer has improved, prognoses for patients remain poor with a 5-year survival rate of < 5%. Angiogenesis, namely, the formation of new blood vessels from pre-existing vessels, is an important event in tumor growth and hematogenous metastasis. It is a dynamic and complex process involving multiple mechanisms and is regulated by various molecules. Inhibition of angiogenesis has been an established therapeutic strategy for many solid tumors. However, clinical outcomes are far from satisfying for pancreatic cancer patients receiving anti-angiogenic therapies. In this review, we summarize the current status of angiogenesis in pancreatic cancer research and explore the reasons for the poor efficacy of anti-angiogenic therapies, aiming to identify some potential therapeutic targets that may enhance the effectiveness of anti-angiogenic treatments.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
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Inibidores da Angiogênese
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Neovascularização Patológica
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article