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Bacillus thuringiensis produces the lipopeptide thumolycin to antagonize microbes and nematodes.
Zheng, Dehong; Zeng, Zhiyong; Xue, Bingbing; Deng, Yaoyao; Sun, Ming; Tang, Ya-Jie; Ruan, Lifang.
Afiliação
  • Zheng D; State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China; College of Agriculture, Guangxi University, Nanning 530004, PR China.
  • Zeng Z; State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China.
  • Xue B; State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China.
  • Deng Y; State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China.
  • Sun M; State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China.
  • Tang YJ; Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, PR China.
  • Ruan L; State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China. Electronic address: ruanlifang@mail.hzau.edu.cn.
Microbiol Res ; 215: 22-28, 2018 Oct.
Article em En | MEDLINE | ID: mdl-30172305
Bacillus thuringiensis has been widely used as a bio-insecticide. However, novel biological activities other than insect toxicity of B. thuringiensis are still underestimated. In this study, a new lipopeptide biosynthesis gene cluster in B. thuringiensis BMB171 was discovered by genome mining and verified by reverse genetics. Thumolycin, the lipopeptide synthesized by this gene cluster, was then isolated and purified. Mass spectrum analysis revealed the molecular mass of thumolycin is 696.51 Da with the predicted molecular formula of C38H64N8O4. Further bioactivities assay showed that thumolycin endowed B. thuringiensis BMB171 with broad spectrum antimicrobial and nematocidal activities.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bacillus thuringiensis / Lipopeptídeos / Agentes de Controle Biológico / Anti-Infecciosos / Nematoides Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bacillus thuringiensis / Lipopeptídeos / Agentes de Controle Biológico / Anti-Infecciosos / Nematoides Idioma: En Ano de publicação: 2018 Tipo de documento: Article