Rodent Behavioral Testing to Assess Functional Deficits Caused by Microelectrode Implantation in the Rat Motor Cortex.
J Vis Exp
; (138)2018 Aug 18.
Article
em En
| MEDLINE
| ID: mdl-30176008
ABSTRACT
Medical devices implanted in the brain hold tremendous potential. As part of a Brain Machine Interface (BMI) system, intracortical microelectrodes demonstrate the ability to record action potentials from individual or small groups of neurons. Such recorded signals have successfully been used to allow patients to interface with or control computers, robotic limbs, and their own limbs. However, previous animal studies have shown that a microelectrode implantation in the brain not only damages the surrounding tissue but can also result in functional deficits. Here, we discuss a series of behavioral tests to quantify potential motor impairments following the implantation of intracortical microelectrodes into the motor cortex of a rat. The methods for open field grid, ladder crossing, and grip strength testing provide valuable information regarding the potential complications resulting from a microelectrode implantation. The results of the behavioral testing are correlated with endpoint histology, providing additional information on the pathological outcomes and impacts of this procedure on the adjacent tissue.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Comportamento Animal
/
Eletrodos Implantados
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Microeletrodos
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Córtex Motor
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article