Pathophysiology and inhibition of IL-23 signaling in psoriatic arthritis: A molecular insight.
Clin Immunol
; 206: 15-22, 2019 09.
Article
em En
| MEDLINE
| ID: mdl-30196070
ABSTRACT
Psoriatic arthritis (PsA) is a chronic inflammatory arthritis of unknown etiology, and currently the cellular and molecular interactions that dictate its pathogenesis remain elusive. A role of the interleukin-23 (IL-23)/IL-23R (IL-23 receptor) interaction in the development of psoriasis and PsA is well established. As IL-23 regulates the differentiation and activation of innate and adaptive immunity, it pertains to a very complex pathophysiology involving a plethora of effectors and transducers. In this review, we will discuss recent advances on the cellular and molecular pathophysiological mechanisms that regulate the initiation and progression of PsA as well as new therapeutic approaches for IL-23/IL-23R targeted therapeutics.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Artrite Psoriásica
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Fármacos Dermatológicos
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Interleucina-23
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article