Comparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin Biosynthesis.
Org Lett
; 20(18): 5918-5921, 2018 09 21.
Article
em En
| MEDLINE
| ID: mdl-30212211
ABSTRACT
Comparative analyses of the four known anthraquinone-fused enediynes biosynthetic gene clusters identified four genes, tnmE6, tnmH, tnmL, and tnmQ, unique to the tnm gene cluster. Larger scale fermentation of both the S. sp. CB03234 wild-type and the Δ tnmH and Δ tnmL mutant strains resulted in the characterization of 20 new tiancimycin (TNM) congeners, including five enediynes. These findings enabled a proposal for the late stage of TNM biosynthesis featuring an intermediate possibly common for all anthraquinone-fused enediynes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Família Multigênica
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Antraquinonas
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Enedi-Inos
/
Luz
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article