Preconditioning of bone marrow-derived mesenchymal stem cells with N-acetyl-L-cysteine enhances bone regeneration via reinforced resistance to oxidative stress.

Watanabe, Jun; Yamada, Masahiro; Niibe, Kunimichi; Zhang, Maolin; Kondo, Takeru; Ishibashi, Minoru; Egusa, Hiroshi

Watanabe, Jun; Yamada, Masahiro; Niibe, Kunimichi; Zhang, Maolin; Kondo, Takeru; Ishibashi, Minoru; Egusa, Hiroshi.

Afiliação

Watanabe J; Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, Sendai, Miyagi 980-8575, Japan.
Yamada M; Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, Sendai, Miyagi 980-8575, Japan. Electronic address: masahiro.yamada.a2@tohoku.ac.jp.
Niibe K; Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, Sendai, Miyagi 980-8575, Japan.
Zhang M; Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, Sendai, Miyagi 980-8575, Japan.
Kondo T; Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, Sendai, Miyagi 980-8575, Japan.
Ishibashi M; Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, Sendai, Miyagi 980-8575, Japan.
Egusa H; Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, Sendai, Miyagi 980-8575, Japan; Center for Advanced Stem Cell and Regenerative Research, Tohoku University Graduate School of Dentistry, Sendai, Miyagi 980-8575, Japan.

Biomaterials ; 185: 25-38, 2018 12.

Article em En | MEDLINE | ID: mdl-30216807

Assuntos

Acetilcisteína/farmacologia; Antioxidantes/farmacologia; Transplante de Células-Tronco Mesenquimais; Células-Tronco Mesenquimais/efeitos dos fármacos; Animais; Apoptose/efeitos dos fármacos; Regeneração Óssea/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Células Cultivadas; Glutationa/metabolismo; Masculino; Transplante de Células-Tronco Mesenquimais/métodos; Células-Tronco Mesenquimais/citologia; Estresse Oxidativo/efeitos dos fármacos; Ratos Sprague-Dawley

Palavras-chave

Acute inflammation; Apoptosis; Cell conditioning; Glutathione; Local transplantation; Senescence

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acetilcisteína / Transplante de Células-Tronco Mesenquimais / Células-Tronco Mesenquimais / Antioxidantes Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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