Effect of metformin on exercise capacity: A meta-analysis.
Diabetes Res Clin Pract
; 144: 270-278, 2018 Oct.
Article
em En
| MEDLINE
| ID: mdl-30217594
ABSTRACT
AIMS:
To evaluate the effect of metformin on various parameters of exercise capacity [oxygen consumption (VO2), peak oxygen consumption (VO2peak), heart rate (HR), exercise test duration, respiratory exchange ratio (RER), rating of perceived exertion (RPE), lactate and ventilatory anaerobic threshold (VAT)].METHODS:
Studies reporting change in VO2 or VO2peak after metformin administration were included. Subgroup analyses were performed as applicable. Mean difference with 95% CIs were pooled using random-effects model [RevMan (v5.3)].RESULTS:
There were no changes in VO2 and VO2peak in the overall population [VO2 nâ¯=â¯388, mean difference -0.12â¯ml/kg/min, 95% CI -0.74, 0.51, pâ¯=â¯0.71 (i2â¯=â¯0%, pâ¯=â¯0.99); VO2peak nâ¯=â¯345, mean difference 0.41â¯ml/kg/min, 95% CI -0.51, 1.33, pâ¯=â¯0.38 (i2â¯=â¯0%, pâ¯=â¯0.89)], healthy volunteers and patients (type 2 diabetes mellitus, insulin resistance, impaired glucose tolerance/impaired fasting glucose and metabolic syndrome). For patients with insulin resistance, there was a decrease in VO2peak, but not VO2. In the overall population, there was a significant decrease in HR and RER, a significant increase in RPE, and no changes in exercise test duration and VAT. In addition, there was an increased VAT in the healthy volunteers.CONCLUSIONS:
In the overall population, metformin did not affect VO2, VO2peak, exercise test duration and VAT, although it significantly decreased HR, RER and increased RPE.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Consumo de Oxigênio
/
Exercício Físico
/
Troca Gasosa Pulmonar
/
Diabetes Mellitus Tipo 2
/
Frequência Cardíaca
/
Hipoglicemiantes
/
Metformina
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article