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Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16.
Shi, Chang-He; Rubel, Carrie; Soss, Sarah E; Sanchez-Hodge, Rebekah; Zhang, Shuo; Madrigal, Sabrina C; Ravi, Saranya; McDonough, Holly; Page, Richard C; Chazin, Walter J; Patterson, Cam; Mao, Cheng-Yuan; Willis, Monte S; Luo, Hai-Yang; Li, Yu-Sheng; Stevens, Donte A; Tang, Mi-Bo; Du, Pan; Wang, Yao-He; Hu, Zheng-Wei; Xu, Yu-Ming; Schisler, Jonathan C.
Afiliação
  • Shi CH; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
  • Rubel C; McAllister Heart Institute at The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
  • Soss SE; Departments of Biochemistry and Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America.
  • Sanchez-Hodge R; McAllister Heart Institute at The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
  • Zhang S; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
  • Madrigal SC; McAllister Heart Institute at The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
  • Ravi S; McAllister Heart Institute at The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
  • McDonough H; McAllister Heart Institute at The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
  • Page RC; Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio, United States of America.
  • Chazin WJ; Departments of Biochemistry and Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America.
  • Patterson C; The Office of the Chancellor, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.
  • Mao CY; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
  • Willis MS; McAllister Heart Institute at The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
  • Luo HY; Department of Pharmacology, and Department of Pathology and Lab Medicine at The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
  • Li YS; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
  • Stevens DA; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
  • Tang MB; McAllister Heart Institute at The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
  • Du P; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
  • Wang YH; National Center for International Research in Cell and Gene Therapy, Sino-British Research Centre for Molecular Oncology, School of Basic Medical Sciences, Academy of Medical Sciences, at Zhengzhou University, Zhengzhou, Henan, China.
  • Hu ZW; National Center for International Research in Cell and Gene Therapy, Sino-British Research Centre for Molecular Oncology, School of Basic Medical Sciences, Academy of Medical Sciences, at Zhengzhou University, Zhengzhou, Henan, China.
  • Xu YM; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
  • Schisler JC; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
PLoS Genet ; 14(9): e1007664, 2018 09.
Article em En | MEDLINE | ID: mdl-30222779
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cognição / Ataxias Espinocerebelares / Ubiquitina-Proteína Ligases / Domínios Proteicos / Atividade Motora Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cognição / Ataxias Espinocerebelares / Ubiquitina-Proteína Ligases / Domínios Proteicos / Atividade Motora Idioma: En Ano de publicação: 2018 Tipo de documento: Article