Cortical Inflammation is Increased in a DSS-Induced Colitis Mouse Model.
Neurosci Bull
; 34(6): 1058-1066, 2018 Dec.
Article
em En
| MEDLINE
| ID: mdl-30225764
ABSTRACT
While inflammatory bowel disease (IBD) might be a risk factor in the development of brain dysfunctions, the underlying mechanisms are largely unknown. Here, mice were treated with 5% dextran sodium sulfate (DSS) in drinking water and sacrificed on day 7. The serum level of IL-6 increased, accompanied by elevation of the IL-6 and TNF-α levels in cortical tissue. However, the endotoxin concentration in plasma and brain of mice with DSS-induced colitis showed a rising trend, but with no significant difference. We also found significant activation of microglial cells and reduction in occludin and claudin-5 expression in the brain tissue after DSS-induced colitis. These results suggested that DSS-induced colitis increases systemic inflammation which then results in cortical inflammation via up-regulation of serum cytokines. Here, we provide new information on the impact of colitis on the outcomes of cortical inflammation.
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Base de dados:
MEDLINE
Assunto principal:
Córtex Cerebral
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Citocinas
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Sulfato de Dextrana
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Colite
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Encefalite
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article