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Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones.
Roed, Nikolaj Kulahin; Viola, Cristina M; Kristensen, Ole; Schluckebier, Gerd; Norrman, Mathias; Sajid, Waseem; Wade, John D; Andersen, Asser Sloth; Kristensen, Claus; Ganderton, Timothy R; Turkenburg, Johan P; De Meyts, Pierre; Brzozowski, Andrzej M.
Afiliação
  • Roed NK; Global Research, Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark.
  • Viola CM; York Structural Biology Laboratory, Department of Chemistry, The University of York, Heslington, York, YO10 5DD, UK.
  • Kristensen O; Department of Drug Design and Pharmacology, University of Copenhagen, DK-2100, Copenhagen Ø, Denmark.
  • Schluckebier G; Global Research, Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark.
  • Norrman M; Global Research, Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark.
  • Sajid W; Global Research, Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark.
  • Wade JD; Florey Institute of Neuroscience & Mental Health, University of Melbourne, Parkville, VIC, 3010, Australia.
  • Andersen AS; School of Chemistry, University of Melbourne, Parkville, VIC, 3010, Australia.
  • Kristensen C; Global Research, Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark.
  • Ganderton TR; Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, DK-2100, Copenhagen N, Denmark.
  • Turkenburg JP; York Structural Biology Laboratory, Department of Chemistry, The University of York, Heslington, York, YO10 5DD, UK.
  • De Meyts P; York Structural Biology Laboratory, Department of Chemistry, The University of York, Heslington, York, YO10 5DD, UK.
  • Brzozowski AM; Global Research, Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark.
Nat Commun ; 9(1): 3860, 2018 09 21.
Article em En | MEDLINE | ID: mdl-30242155
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Ligação a Fator de Crescimento Semelhante a Insulina / Proteínas de Drosophila Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Ligação a Fator de Crescimento Semelhante a Insulina / Proteínas de Drosophila Idioma: En Ano de publicação: 2018 Tipo de documento: Article