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PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-ß1 production.
Celada, Lindsay J; Kropski, Jonathan A; Herazo-Maya, Jose D; Luo, Weifeng; Creecy, Amy; Abad, Andrew T; Chioma, Ozioma S; Lee, Grace; Hassell, Natalie E; Shaginurova, Guzel I; Wang, Yufen; Johnson, Joyce E; Kerrigan, Amy; Mason, Wendi R; Baughman, Robert P; Ayers, Gregory D; Bernard, Gordon R; Culver, Daniel A; Montgomery, Courtney G; Maher, Toby M; Molyneaux, Philip L; Noth, Imre; Mutsaers, Steven E; Prele, Cecilia M; Peebles, R S; Newcomb, Dawn C; Kaminski, Naftali; Blackwell, Timothy S; Van Kaer, Luc; Drake, Wonder P.
Afiliação
  • Celada LJ; Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. wonder.drake@vanderbilt.edu lindsay.j.celada@vanderbilt.edu.
  • Kropski JA; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Herazo-Maya JD; Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
  • Luo W; Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Creecy A; Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
  • Abad AT; Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Chioma OS; Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Lee G; Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Hassell NE; Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Shaginurova GI; Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Wang Y; Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Johnson JE; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Kerrigan A; Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Mason WR; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Baughman RP; Division of Pulmonary, Critical Care and Sleep Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45219, USA.
  • Ayers GD; Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Bernard GR; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Culver DA; Respiratory Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Montgomery CG; Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
  • Maher TM; Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73126, USA.
  • Molyneaux PL; National Institute for Health Research Respiratory Biomedical Research Unit, Royal Brompton Hospital, London SW7 2AZ, UK.
  • Noth I; Fibrosis Research Group, National Heart and Lung Institute, Imperial College, London SW7 2AZ, UK.
  • Mutsaers SE; National Institute for Health Research Respiratory Biomedical Research Unit, Royal Brompton Hospital, London SW7 2AZ, UK.
  • Prele CM; Fibrosis Research Group, National Heart and Lung Institute, Imperial College, London SW7 2AZ, UK.
  • Peebles RS; Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL 60637, USA.
  • Newcomb DC; Centre for Cell Therapy and Regenerative Medicine, School of Biomedical Sciences, University of Western Australia, Nedlands, Western Australia 6009, Australia.
  • Kaminski N; Institute for Respiratory Health, Centre for Respiratory Health, School of Biomedical Sciences, University of Western Australia, Nedlands, Western Australia 6009, Australia.
  • Blackwell TS; Centre for Cell Therapy and Regenerative Medicine, School of Biomedical Sciences, University of Western Australia, Nedlands, Western Australia 6009, Australia.
  • Van Kaer L; Institute for Respiratory Health, Centre for Respiratory Health, School of Biomedical Sciences, University of Western Australia, Nedlands, Western Australia 6009, Australia.
  • Drake WP; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Sci Transl Med ; 10(460)2018 09 26.
Article em En | MEDLINE | ID: mdl-30257954
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Regulação para Cima / Interleucina-17 / Fator de Transcrição STAT3 / Fator de Crescimento Transformador beta1 / Fibrose Pulmonar Idiopática / Receptor de Morte Celular Programada 1 Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Regulação para Cima / Interleucina-17 / Fator de Transcrição STAT3 / Fator de Crescimento Transformador beta1 / Fibrose Pulmonar Idiopática / Receptor de Morte Celular Programada 1 Idioma: En Ano de publicação: 2018 Tipo de documento: Article