Cholesterol Modification Enhances Antimetastatic Activity and siRNA Delivery Efficacy of Poly(ethylenimine)-Based CXCR4 Antagonists.

Wu, Pengkai; Luo, Xingping; Wu, Hui; Yu, Fei; Wang, Kaikai; Sun, Minjie; Oupicky, David

Wu, Pengkai; Luo, Xingping; Wu, Hui; Yu, Fei; Wang, Kaikai; Sun, Minjie; Oupicky, David.

Afiliação

Wu P; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, China.
Luo X; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, China.
Wu H; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, China.
Yu F; Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Wang K; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, China.
Sun M; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, China.
Oupicky D; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, China.

Macromol Biosci ; 18(11): e1800234, 2018 11.

Article em En | MEDLINE | ID: mdl-30259651

Assuntos

Portadores de Fármacos; Neoplasias Mamárias Experimentais/tratamento farmacológico; Proteínas de Neoplasias/antagonistas & inibidores; Polietilenoimina; RNA Interferente Pequeno; Receptores CXCR4/antagonistas & inibidores; Animais; Linhagem Celular Tumoral; Portadores de Fármacos/química; Portadores de Fármacos/farmacologia; Feminino; Neoplasias Mamárias Experimentais/genética; Neoplasias Mamárias Experimentais/metabolismo; Neoplasias Mamárias Experimentais/patologia; Camundongos; Camundongos Endogâmicos BALB C; Metástase Neoplásica; Proteínas de Neoplasias/genética; Proteínas de Neoplasias/metabolismo; Polietilenoimina/química; Polietilenoimina/farmacologia; RNA Interferente Pequeno/química; RNA Interferente Pequeno/farmacologia; Receptores CXCR4/genética; Receptores CXCR4/metabolismo

Palavras-chave

CXCR4 antagonist; breast cancer; polyethylenimine; siRNA delivery

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polietilenoimina / Portadores de Fármacos / Receptores CXCR4 / RNA Interferente Pequeno / Neoplasias Mamárias Experimentais / Proteínas de Neoplasias Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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