Artemisinin attenuates tubulointerstitial inflammation and fibrosis via the NF-&#954;B/NLRP3 pathway in rats with 5/6 subtotal nephrectomy.

Wen, Yi; Pan, Ming-Ming; Lv, Lin-Li; Tang, Tao-Tao; Zhou, Le-Ting; Wang, Bin; Liu, Hong; Wang, Feng-Mei; Ma, Kun-Ling; Tang, Ri-Ning; Liu, Bi-Cheng

Artemisinin attenuates tubulointerstitial inflammation and fibrosis via the NF-κB/NLRP3 pathway in rats with 5/6 subtotal nephrectomy.

Wen, Yi; Pan, Ming-Ming; Lv, Lin-Li; Tang, Tao-Tao; Zhou, Le-Ting; Wang, Bin; Liu, Hong; Wang, Feng-Mei; Ma, Kun-Ling; Tang, Ri-Ning; Liu, Bi-Cheng.

Afiliação

Wen Y; Department of Nephrology Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.
Pan MM; Department of Nephrology Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.
Lv LL; Department of Nephrology Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.
Tang TT; Department of Nephrology Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.
Zhou LT; Department of Nephrology Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.
Wang B; Department of Nephrology Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.
Liu H; Department of Nephrology Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.
Wang FM; Department of Nephrology Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.
Ma KL; Department of Nephrology Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.
Tang RN; Department of Nephrology Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.
Liu BC; Department of Nephrology Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.

J Cell Biochem ; 120(3): 4291-4300, 2019 03.

Article em En | MEDLINE | ID: mdl-30260039

Assuntos

Anti-Inflamatórios/uso terapêutico; Artemisininas/uso terapêutico; NF-kappa B/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Nefrectomia/efeitos adversos; Nefrite Intersticial/tratamento farmacológico; Nefrite Intersticial/etiologia; Animais; Anti-Inflamatórios/farmacologia; Artemisia/química; Artemisininas/farmacologia; Linhagem Celular; Células Epiteliais/efeitos dos fármacos; Células Epiteliais/metabolismo; Fibrose; Humanos; Inflamassomos/efeitos dos fármacos; Inflamassomos/metabolismo; Rim/citologia; Rim/patologia; Masculino; Extratos Vegetais/uso terapêutico; Ratos; Ratos Sprague-Dawley; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

NF-κB/NLRP3; artemisinin (Art); tubulointerstitial inflammation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: NF-kappa B / Artemisininas / Proteína 3 que Contém Domínio de Pirina da Família NLR / Anti-Inflamatórios / Nefrectomia / Nefrite Intersticial Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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