A prospective, randomized, double-blinded, placebo-controlled clinical study on postoperative antibiotherapy in 150 arthroscopy-assisted tibial plateau leveling osteotomies in dogs.
Vet Surg
; 47(8): E79-E87, 2018 Nov.
Article
em En
| MEDLINE
| ID: mdl-30267441
ABSTRACT
OBJECTIVE:
To determine the influence of a 7-day course of postoperative antibiotherapy (cefpodoxime) on surgical site infections (SSI) after tibial plateau leveling osteotomy (TPLO). STUDYDESIGN:
Prospective, randomized, double-blinded, placebo-controlled clinical study. SAMPLE POPULATION One hundred fifty client-owned dogs, with consent.METHODS:
Dogs undergoing arthroscopy-assisted TPLO were randomly assigned to 1 of 2 groups, the placebo group receiving perioperative cefazolin and 7 days of placebo medication after surgery or the treatment group receiving perioperative cefazolin and 7 days of postoperative cefpodoxime. Twenty-seven factors were analyzed for association with SSI by using univariate analysis, Fisher's exact test, or Wilcoxon rank-sum test.RESULTS:
SSI rates did not differ (P = .34) between the placebo group (17%; 95% confidence level [CL] 7.94%-26.43%) and the treatment group (11% SSI; 95% CL 3.98%-18.88%). The probability that > 23% of dogs would benefit from postoperative antibiotherapy was less than 5%. The only association between the factors tested in this study and SSI involved the body weight (kg), with each 1 unit increase in kilogram weight increasing the odds of developing an SSI by 4.7%.CONCLUSION:
Although the wide CL may be consistent with a type II error, a 7-day course of cefpodoxime after arthroscopy-assisted TPLO did not influence postoperative SSI in the population tested here. In addition, only a small proportion of dogs would benefit from postoperative antibiotherapy under the conditions of our study. CLINICALSIGNIFICANCE:
These results should prompt surgeons to reconsider systematic antibiotherapy after TPLO and justify additional studies to determine whether dogs predisposed to infection could benefit from such an approach.
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Base de dados:
MEDLINE
Assunto principal:
Osteotomia
/
Artroscopia
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Infecção da Ferida Cirúrgica
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Tíbia
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Cães
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article