The time-course of the inflammatory response to major burn injury and its relation to organ failure and outcome.
Burns
; 45(2): 354-363, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30274808
ABSTRACT
Burn injury causes major inflammatory activation and cytokine release, however, the temporal resolution of the acute and sub-acute inflammatory response has not yet been fully delineated. To this end, we have quantified 20 inflammatory mediators in plasma from 44 adult patients 0-21 days after burn injury and related the time course of these mediators to % total body surface area (TBSA) burned, clinical parameters, organ failure and outcome. Of the cytokines analyzed in these patients, interleukin 6 (IL-6), IL-8, IL-10 and monocyte chemoattractant protein 1 (MCP-1) correlated to the size of the injury at 24-48h after burn injury. In our study, the concentration of IL-10 had prognostic value in patients with burn injury both measured at admission and at 24-48h after injury. However, simple demographic data such as age, % burned TBSA, inhalation injury and their combination, the Baux score and modified Baux score, outperform most of the cytokines, with the exception of IL-8 and MCP-1 levels on admission, in predicting death.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Queimaduras
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Citocinas
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Inflamação
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article