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Tenofovir Exposure during Pregnancy and Postpartum in Women Receiving Tenofovir Disoproxil Fumarate for the Prevention of Mother-to-Child Transmission of Hepatitis B Virus.
Cressey, Tim R; Harrison, Linda; Achalapong, Jullapong; Kanjanavikai, Prateep; Patamasingh Na Ayudhaya, Orada; Liampongsabuddhi, Prateung; Siriwachirachai, Thitiporn; Putiyanun, Chaiwat; Suriyachai, Pornnapa; Tierney, Camlin; Salvadori, Nicolas; Chinwong, Dujrudee; Decker, Luc; Tawon, Yardpiroon; Murphy, Trudy V; Ngo-Giang-Huong, Nicole; Siberry, George K; Jourdain, Gonzague.
Afiliação
  • Cressey TR; PHPT/IRD, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand tim.cressey@phpt.org.
  • Harrison L; Department of Immunology & Infectious Diseases, Boston, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
  • Achalapong J; Department of Molecular & Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom.
  • Kanjanavikai P; Center for Biostatistics in AIDS Research (CBAR), Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
  • Patamasingh Na Ayudhaya O; Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand.
  • Liampongsabuddhi P; Banglamung Hospital, Chonburi, Thailand.
  • Siriwachirachai T; Nopparat Rajathanee Hospital, Bangkok, Thailand.
  • Putiyanun C; Lampang Hospital, Lampang, Thailand.
  • Suriyachai P; Khon Kaen Hospital, Khon Kaen, Thailand.
  • Tierney C; Chiang Kham Hospital, Phayao, Thailand.
  • Salvadori N; Phayao Provincial Hospital, Phayao, Thailand.
  • Chinwong D; Center for Biostatistics in AIDS Research (CBAR), Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
  • Decker L; PHPT/IRD, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
  • Tawon Y; Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand.
  • Murphy TV; Institut de Recherche pour le Développement (IRD), Unité Mixte Internationale 174-PHPT, Chiang Mai, Thailand.
  • Ngo-Giang-Huong N; PHPT/IRD, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
  • Siberry GK; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Jourdain G; PHPT/IRD, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Antimicrob Agents Chemother ; 62(12)2018 12.
Article em En | MEDLINE | ID: mdl-30275094
ABSTRACT
We assessed tenofovir exposure during pregnancy and postpartum in hepatitis B virus (HBV)-infected HIV-uninfected women receiving tenofovir disoproxil fumarate (TDF) to prevent mother-to-child transmission of HBV. Data from 154 women who received TDF within a randomized controlled trial were included. Individual plasma tenofovir exposures (area under the concentration-time curve from 0 to 24 h [AUC0-24]) were estimated using a population pharmacokinetic approach. The estimated geometric mean tenofovir AUC0-24 was 20% (95% confidence interval [95% CI], 19 to 21%) lower during pregnancy than during postpartum; this modest reduction in the absence of HBV transmission suggests that no dose adjustment is needed.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Vírus da Hepatite B / Transmissão Vertical de Doenças Infecciosas / Hepatite B Crônica / Tenofovir Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Vírus da Hepatite B / Transmissão Vertical de Doenças Infecciosas / Hepatite B Crônica / Tenofovir Idioma: En Ano de publicação: 2018 Tipo de documento: Article