Granulocyte colony-stimulating factor and respiratory status of critically ill neutropenic patients with hematologic malignancies.
Leuk Lymphoma
; 60(5): 1156-1163, 2019 05.
Article
em En
| MEDLINE
| ID: mdl-30277108
ABSTRACT
In patients with hematologic malignancies, respiratory status may deteriorate during neutropenia recovery. This multicenter, observational study aims to evaluate granulocyte colony-stimulating factor (G-CSF) impact on respiratory status in critically ill neutropenic patients. Among 1011 critically ill patients with hematologic malignancies, 288 were neutropenic and included in this study. 201 (70%) did not receive G-CSF at day 1 or 2. After propensity score matching for the probability of receiving G-CSF at day 1 or 2, there was no association between G-CSF and respiratory deterioration at day 14 (OR =1.19; 95%CI (0.57-2.51); p = .64). Additional sensitivity analysis in patients admitted for acute respiratory failure showed similar results (OR =1.34; 95%CI (0.5-3.59); p = .57). Among patients who recovered from neutropenia, 75% experienced respiratory deterioration during neutropenia recovery. This study confirms that neutropenia recovery is a situation at risk of respiratory deterioration. However, whether G-CSF is an aggravating factor cannot be supported by our results.
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MEDLINE
Assunto principal:
Respiração
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Fator Estimulador de Colônias de Granulócitos
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Estado Terminal
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Neoplasias Hematológicas
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Neutropenia
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article